Advanced Authentic Research

Pharmacokinetics and Pharmacodynamics of Propofol in Bariatric Subjects by Jenna O.


This project will analyze the effect of obesity on the pharmacokinetics and pharmacodynamics of propofol.  Propofol is the most commonly used intravenous drug for induction of anesthesia.  Currently, all recommended dosing regimens are based upon work done in normal weight subjects.  To data, very little is published on the necessary dose or weight-based scalar to use in bariatric patients.  This is troublesome as propofol has a very narrow therapeutic window.  If too little drug is given, subjects have an increased risk for awareness during anesthesia.  If too much drug is given, adverse side effects such as hypotension are likely.  This study will analyze the proper dosing regimen for propofol in this patient population.  Results of this study will allow clinicians to administer propofol safely and more effectively in this patient population...