To investigate the effects of fentanyl on high school students' academic success and develop targeted prevention strategies. The primary purpose is to raise awareness about the dangers of fentanyl, especially in the Bay Area, where overdose rates are increasing. By examining the parallels between fentanyl and historical substance use patterns, the focus is on the need for comprehensive prevention and intervention strategies. The study not only contributes to understanding the impact of drugs on academic success but also aims to benefit schools and districts by facilitating knowledge exchange and enhancing outreach efforts. Ultimately, the research findings will inform and improve drug prevention initiatives in the Bay Area.