The COVID-19 pandemic taking the lives of an estimated 18.2 million revealed gaps in worldwide public health systems and pandemic preparedness. Many developed nations started incorporating the One Health approach into their public health systems and recognizing its advantages (Sinclair, 2019). One Health is an inclusive approach for healthcare systems that recognizes the interconnectedness of human, animal, and environmental health (WHO, 2021). Low and middle-income countries, mostly in Southeast Asia, South Asia, and Africa fail to recognize the holistic approach of One Health (Yopa et al., 2023). Zoonotic diseases have a higher impact in LMICs due to rapid population growth, a lack of infrastructure, weak immune systems, and lifestyles that depend on animals for food (Wondwossen et al, 2014). This begs the question: How implementation of the One Health approach into the public health systems of low and middle-income countries (LMICs) influence the success of addressing zoonotic diseases? Evaluation research will be used to evaluate the effectiveness of One Health approach implementations. Databases will be used to find graphics, reports, scripts, and tables of public health systems. Coding will be utilized to condense data into 5-7 themes that integrate categories, subcategories, and themes into an argument.