Understanding gut bacteria’s effect on the onset of neurodegenerative diseases


by : 
Wendy X. and Christine Z.


This research project will study the connection between the gut microbiome alterations and contributing proteins, such as Tau and beta-amyloid, alpha-synuclein, and Huntingtin, analyzing their specific structure and function in Alzheimer’s, Parkinson’s, and Huntington’s diseases respectively. Previous studies have shown a possible relationship between gut microbiome bacteria and the eventual aggregating and misfolding of proteins. Abnormal misfolded proteins interrupt intercellular communication and secrete toxins, and this action typically triggers the onset of those diseases. This project will utilize BLAST to inspect similarities between the molecular structures of these proteins. Results will provide a better understanding of each disease and potentially come up with an idea of how to combat all these neurodegenerative diseases.

Personal Statement

As a continuation of our project from last year, my partner and I delved deeper into neurodegenerative diseases. Our project this year allowed us to better comprehend the similarities between the proteins involved in Alzheimer's, Parkinson's, and Huntington's diseases, as well as the relationship between the development of those diseases and the gut microbiome. Not only did we gain knowledge of the pathology of these diseases, but we were also able to investigate current clinical trials and potential treatments.